In contrast to HLA class Ia, expression of HLA-G is usually confined to the placenta and certain immune-privileged tissues; however, ectopic expression was found in many different tumor entities (Ben Amor et al. 2016; Leleu et al. 2005; Rebmann et al. 2003; Sebti et al. 2007) where it is thought to feature a tolerogenic effect on different subsets of immune cells including CD56+ NK cells, CD4+/CD8+ T cells, and B cells. This evidence concerns the gene NCAM1 and neoplasm.