SEPTIN7 and Alzheimer disease: Septin 7 can increase the spine density and reduce spine size in female p25 transgenic mice.72 Meanwhile, in water maze experiments septin 7 level was increased in trained mice but not in control mice, which indicates that septin 7 expression is up‐regulated during spatial memory formation.66 As the synapse has been identified to be affected in early AD73 and the association between the septin 7 and p25, investigating the role of septin 7 can have a profound effect on AD treatment.