Clozapine is a kind of antipsychotics by regulating dopamine receptor D2 and other neurotransmitter receptors.72 Low expression of septin 7 leads to the abnormal spine density in the prefrontal cortex of schizophrenia patients.84, 85 Interestingly, septin 7 levels are reduced in prefrontal cortex of male mice, but not in female mice86 and the sex differences in the septin 7 levels in schizophrenia and AD are the complete opposites. This evidence concerns the gene SEPTIN7 and Alzheimer disease.