CDK5 and Alzheimer disease: Cdk5 signalling can alter expression of various candidate genes related to schizophrenia.74, 75, 76 Reduction of the level of p35, as Cdk5 activator,66 is sufficient to reduce septin 7 expression.72 Cdk5 activity can be regulated by the glutamatergic and dopaminergic cell signalling.77, 78, 79, 80 In addition,the dysfunction of the TAOK2 and septins are found in the neurofibrillary tangles in AD,81 which may offer a novel pathway to treat AD.