SEPTIN7 and Alzheimer disease: Reduction of p25 levels contributes to memory formation in early AD,67, 68 while the ongoing overexpression of p25 leads to neurodegeneration in later AD.69, 70 Septin 7 has been suggested to be a p25‐regulated protein localized in spine necks, where it can control the formation and shape of spines.12, 38, 71 Low expression of septin 7 induces lower spine density and increased size of spines in vivo.14, 40 Interestingly, septin 7 expression was specifically up‐regulated in female, but not male mice.