CFL1 and central nervous system cancer: Moreover, upon overexpression septin 7 can bind to actin filaments and promote F‐actin ring formation to inhibit the migration of glioma cells.99 Increased levels of septin 7 promoted depolymerization of actin filaments via cofilin phospho‐regulation, and the septin 7 knockdown by cofilin phospho‐regulation improved glioma cell motility and accelerated actin polymerization.