TLR4 overexpression promoted cell proliferation, proportion of BrdU‐positive cells, colony formation ability and xenograft tumour formation ability (including xenograft weight and tumour appearance time) of hLCSCs; however, these actions were fully abrogated by depletion of HP1α, HP1β, HP1γ, HP1(α, β, γ)(Figure 7G‐J). The gene discussed is TLR4; the disease is neoplasm.