PRDM9 and cancer: In addition, epigenetic engineering shows that a human centromere can resist silencing, which is mediated by H3K27me3/K9me3.29 Suppressor of variegation 3‐9 homologue 2 (SUV39 h2) is a SET domain‐containing histone methyltransferase that is up‐regulated in solid cancers,30 which inhibits polyubiquitination in human cancer cells by methylating and stabilizing LSD1.31 Our results suggest that TLR4 promotes trimethylation of histone H3 at lysine 9.