Furthermore, overexpression of HP1α, HP1β, HP1γ did not significantly alter cell proliferation, proportion of BrdU‐positive cells, colony formation ability and xenograft tumour formation ability of hLCSCs whose TLR4 was knocked down (Figure 7G‐J, TLR4i+HP1αβγ). The gene discussed is TLR4; the disease is neoplasm.