PPARGC1A and metabolic dysfunction-associated steatohepatitis: Similarly, Wanagat et al also reported that PGC‐1α overexpression increased mitochondrial function, reduced hepatic TG content and improved insulin resistance in primary hepatocytes and Sprague‐Dawley rats,20 further confirming the beneficial role of PGC‐1α on mitochondrial dysfunction and insulin resistance in NASH.