In oxaliplatin‐resistant HCC cells (Huh7/OXA and HepG2/OXA), NR2F1‐AS1 knockdown reduces the mRNA expression levels of drug resistance‐related genes, including MDR1, MRP5, LRP1, which indicate that NR2F1‐AS1 silencing could decrease the oxaliplatin resistance. The gene discussed is LRP1; the disease is hepatocellular carcinoma.