In oxaliplatin‐resistant HCC cells (Huh7/OXA and HepG2/OXA), NR2F1‐AS1 knockdown reduces the mRNA expression levels of drug resistance‐related genes, including MDR1, MRP5, LRP1, which indicate that NR2F1‐AS1 silencing could decrease the oxaliplatin resistance. Here, NR2F1 is linked to hepatocellular carcinoma.