The dysregulated expression of lncRNA provides a valuable clue for the discovery of functional molecular that modulates chemotherapy resistance.21 For chemoresistance of HCC, lncRNAs regulate the chemosensitivity of HCC corresponding to clinical chemotherapeutic drugs.10, 22 For example, lncRNA HULC has been reported to be positively correlated with that of Sirt1 protein in human HCC tissues, stabilizing Sirt1 protein and triggering the autophagy to attenuate the chemosensitivity of HCC cells.23 This evidence concerns the gene SIRT1 and hepatocellular carcinoma.