For example, a nonbiased transcriptomic approach identified cardiac fibroblast ATF3 as being cardioprotective in heart-failure models; and fibroblast p38 was identified as the downstream molecule responsible for profibrotic and hypertrophic effects in fibroblast-specific ATF3 KO mice [Col1a2-Cre-ER(T) model] (73). This evidence concerns the gene MAPK14 and heart failure.