NFKB1 and neoplasm: The tumor suppressive functions of canonical NF-κB may be due to the modulation of NF-κB activity by tumor suppressors such as p53 [6,61,116,117,118] or due to alterations in the phosphorylation status of NF-κB subunits [6,119,120,121] suppressing NF-κB’s ability to induce the expression of genes that are associated with tumor growth and survival.