Mechanical stimulation or manipulation of cells has been shown to cause ATP release from corneal endothelial cells, ovarian granulosa cells, astrocytes, and Cx43-expressing C6 glioma cells in a Cx43-dependent manner, and from renal glomerular endothelial cells via Cx40 hemichannels [7,27,28,29]. Here, GJA1 is linked to glioma.