CD4 and histoplasmosis: It is therefore noteworthy that sub-Saharan African clinicians should think of histoplasmosis in case of a sudden occurrence of poor general condition with CD4 T cells count <100/mm3 in HIV-infected patients [49]; or in a patient suspected of tuberculosis with negative sputum on bacteriology examination, and treated with effective antituberculosis drugs without clinical improvement [36,50]; or in case of a prolonged fever occurring in a HIV+ person or a person of unknown HIV serology status [37,51,52,53,54].