MMP7 is implicated in blood–brain barrier disruption, axonal injury and is involved in shedding of signaling molecules, including TNF, that contribute to the pathology of MS (Chandler et al., 1995; Gearing et al., 1995; Kieseier et al., 1998; Newman et al., 2001; Buhler et al., 2009). Here, TNF is linked to myeloid sarcoma.