FN1 and myeloid sarcoma: Hence, given that microglia/macrophage activation is perturbed in MS lesions (Vogel et al., 2013; Peferoen et al., 2015), upregulation of local MMP7 expression levels, for example by priming microglia/macrophages towards the alternative activated phenotype, may be an attractive approach to locally provoke degradation of fibronectin (aggregates) and thus promote remyelination in MS.