NR3C2 and heart failure: Aldosterone (Aldo) secreted from the adrenal cortex plays a crucial role in regulating renal sodium transport and electrolytic balance through the activation of mineralocorticoid receptor (MR) in the kidney.1, 2 Clinical studies demonstrated that inhibition of MR could decrease the risk of both morbidity and mortality in patients with heart failure, and inhibit albumin excretion in hypertensive and diabetic patients.3, 4, 5 In addition, MR antagonists also present a renoprotective effect in several experimental models of kidney disease.6, 7