For example, upregulated p62 in autophagy‐deficient cells activate the pro‐inflammatory transcription factor NF‐κB.49 Autophagy also prevents tissue inflammation due to its role in apoptotic corpse clearance.30 Recent studies reported that impaired or deficient autophagy is believed to contribute to renal and cardiovascular disease as described in previous studies that focused on the role of autophagy in cardiac‐renal disease,50, 51 but the mechanism is not understood clearly. This evidence concerns the gene NFKB1 and cardiovascular disorder.