ITGAM and autoimmune disease: Although CD11b deficiency has been reported to reduce renal accumulation of inflammatory neutrophils and complement-mediated proteinuria in an acute anti-glomerular basement membrane (GBM) nephritis model (62), it has also been reported to increase susceptibility to chronic inflammatory and autoimmune diseases (38, 41, 60, 61, 63–65) and to exacerbate disease that is associated with elevated neutrophil accumulation in tissue and elevated proteinuria (41, 61).