Accordingly, CCL2 deficiency reduces infiltration of macrophages into blood vessels, lung (Gosling et al., 1999; Dessing et al., 2007) and central nervous system in experimental animal models of inflammatory and neurodegenerative diseases (Huang et al., 2001; Muessel et al., 2002), including HSV-1 encephalitis (Kurt-Jones et al., 2004). The gene discussed is CCL2; the disease is neurodegenerative disease.