As the ATM/mTOR signaling, Rac1-GTPase, and PI3 K/AKT pathways play critical roles in controlling migration of cell [1–4], the multiple cell surface antigens such as CCR2/CD192, CD64/FcγR1, CX3CR1 and Mac3 were linked to origination of monocyte-macrophage differentiation and polarization in post myocardial infarction (MI) [5–9], but the molecular basis of macrophages migrating into specific tissues under physiological or pathological conditions, and fundamental knowledge of cell–cell recognition are much more obscure. The gene discussed is FCGR1A; the disease is myocardial infarction.