The heterogeneity in this polymorphism was contributed mainly by Zhang et al. Removal of this study from meta-analysis gave 0% (p > 0.05) (Allelic contrast: Asian: p = 0.40; APOE ε4+: not available (NA); recessive model: Asian: NA; APOE ε4+: NA) heterogeneity and the result remained none significant, which showed that it had the highest effect on the correction of 5HT2A and AD. This evidence concerns the gene HTR2A and Alzheimer disease.