Subgroups analysis based on ethnicities showed a significant association between allelic and dominant models of 5HT2A (C102T) and AD in Asian subgroup (allelic model: OR = 1.42; 95% CI = 1.14–1.78; dominant model: OR = 1.60; 95% CI = 1.09–2.35). Here, HTR2A is linked to Alzheimer disease.