CXCR2 and clear cell renal carcinoma: In addition, previous studies have demonstrated that CXCR2 plays a critical role in cancers, such as lung cancer [6, 7], laryngeal squamous cell carcinoma [8], astrocytic tumors [9], pancreatic ductal carcinoma [10], clear-cell renal cell carcinoma [11] and hepatocellular carcinoma [12].