For leukaemia, TRIB1, TRIB2 and TRIB3 expression associates with a number of the different subgroups of AML; TRIB1 is both mutated and elevated in acute megakaryocytic leukaemia (AMKL) and AML with 8q amplifications [12–14]; TRIB2 expression associates positively with the AML subset with dysregulated CEBPA [15, 16] and negatively with subgroups with a high frequency of mutated NPM1 and FLT3, however TRIB2 is high in AML with FLT3TKD [10, 17]. Here, NPM1 is linked to acute megakaryoblastic leukemia.