In cells exposed to a combination of EGF and PGE2, BrdU incorporation levels increased at 16 h, doubled at 24 h and declined to baseline at 48 h, indicating that EGF and PGE2 combination-induced nuclear EGFR sustained NSCLC cells growth (Figure 8B–8F). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.