Moreover, we do not observe any enhancement in the modulation of PGE2 activity on nuclear EGFR translocation when NSCLC cells were silenced for Clathrin heavy chain and Caveolin-1 together, suggesting that the two endocytic pathways activated by the prostanoid work independently (Supplementary Figure 3). The gene discussed is CLTC; the disease is non-small cell lung carcinoma.