Collectively, the findings of this work on EGFR nuclear import and gene transcription, assume the character of a self-feeding loop which leads to persistent up-regulation of CCND1, PTGS2, NOS2 and MYC, hence overproduction of PGE2, NO and overload of MYC which support a favorable pro-tumor microenvironment. Here, PTGS2 is linked to neoplasm.