By analyzing the expression of target genes of nuclear EGFR in NSCLC cells, we found that CCND1, PTGS2, MYC and NOS2 mRNA levels were upregulated by EGF as well as by PGE2, yet with different kinetics indicating the involvement of distinct internalization pathways (Figure 6 and Supplementary Figure 6). Here, NOS2 is linked to non-small cell lung carcinoma.