Notably, the tumor burden (as determined by exoDNA and cfDNA mutant KRAS allele fraction) rose from non-detectable to detectable levels when therapy was changed from FOLFIRINOX to Gemcitabine/Abraxane, and thereafter, sharply spiked after the patient received adoptive T-cell therapy, finally regressing once the patient resumed cytotoxic chemotherapy comprised of a “cocktail” of agents, including cisplatin, carboplatin and etoposide (amongst others). Here, KRAS is linked to neoplasm.