These findings suggest that miR-152-3p is transcribed in parallel with its host gene, COPZ2. Exposure of PCa cells to demethylating agent 5-Aza-2-deoxycytidine (5-Aza-CdR) caused a 38 and 67% reduction in COPZ2-miR-152-3p promoter methylation levels, in LNCaP (p = 0.0411) and PC3 cells (p = 0.0043), respectively (Fig. 2h). This evidence concerns the gene COPZ2 and posterior cortical atrophy.