Remarkably, we found that TMEM97 and NOL4 expression levels were significantly upregulated in PCa cases from both cohorts, compared to normal prostate tissues (p = 0.0132 and p = 0.0004, respectively, in IPO Porto’s cohort; p < 0.0001 and p < 0.0001, respectively, in TCGA cohort; Fig. 4f, g). Here, TMEM97 is linked to posterior cortical atrophy.