Additional molecular genetic testing for syndromic and non-syndromic aortic aneurysms was negative.<h4>Conclusions</h4>Many of the patient's features are consistent with individuals reported with 5p13 duplication syndrome and similar cases of SMC5, including polyhydramnios, macrocephaly, dolichocephaly, pre-auricular pits, arachnodactyly, respiratory problems, and developmental delays. This evidence concerns the gene SMC5 and aortic aneurysm.