In addition, the mRNA expression levels of survivin, VEGF and collagen III in BLM + WYHZTL-H group were even lower than BLM + WYHZTL-M group (P < 0.01, P < 0.01, P < 0.05, respectively), while the mRNA expression levels of FN1, collagen I in BLM + WYHZTL-H group were even lower than BLM + XAV-939 group (P < 0.05, P < 0.01, respectively) (Fig. 2g, i–l). The gene discussed is VEGFA; the disease is Bloom syndrome.