GSK3B and Bloom syndrome: The results of RT-qPCR showed that the mRNA expression level of GSK3β in BLM + WYHZTL-H, and BLM + XAV-939 group were significantly higher than that in BLM group (P < 0.01), while BLM + WYHZTL-L, BLM + WYHZTL-M groups had no significant changes (P > 0.05) (Fig. 2d).