Compared to BLM group, the expression level of Wnt1 and β-catenin in BLM + WYHZTL-M, BLM + WYHZTL-H and BLM + XAV-939 group was significantly decreased (P < 0.01, P < 0.001, P < 0.001; all P < 0.001, respectively), while BLM + WYHZTL-L group had no significant changes (P > 0.05) (Fig. 2a, b). This evidence concerns the gene WNT1 and Bloom syndrome.