In addition, the protein expression levels of cyclin D1, CTGF, FN1 in BLM + WYHZTL-H group were even lower than BLM + WYHZTL-M group (all P < 0.001), while the protein expression levels of collagen I in BLM + WYHZTL-H group was lower than BLM + XAV-939 group (P < 0.01). This evidence concerns the gene CCN2 and Bloom syndrome.