And the expression level of β-catenin in BLM + WYHZTL-H was lower than BLM + WYHZTL-M (P < 0.01) and BLM + XAV-939 (P < 0.05) group while the expression level of Wnt1 in BLM + WYHZTL-H were lower than BLM + WYHZTL-M (P < 0.01), other than BLM + XAV-939 group (P > 0.05) (Fig. 2a, b). The gene discussed is WNT1; the disease is Bloom syndrome.