PPARGC1A and ovarian carcinoma: As described above, PGC-1α is decreased in colon [88], breast [89], and ovarian cancer cells [41], and PGC-1α overexpression in human ovarian cancer cell line Ho-8910 has been shown to induce apoptosis via downregulation of Bcl-1 and upregulation of Bax, suggesting that PGC-1α may be a contributor to the inhibition of tumor growth [41].