CYLD and adnexal spiradenoma/cylindroma of a sweat gland: Pseftogas et al. reported that PPARγ activation has a tumor suppressive effect by upregulating the expression of tumor suppressor Cyld, as the Cyld promoter has PPARγ binding sites [32]. Cyld was identified as a tumor suppressor gene that is causally associated with the development of inherited cylindromas [63].