Ultimately, combining the evidence for (1) its localization to the choriocapillaris in high-risk and AMD patients, (2) its role in complement system activation and its interaction with AMD-associated complement proteins, (3) its ability to directly promote CEC activation in vitro and ex vivo, and (4) its pro-inflammatory effects on RPE-choroid tissue, mCRP is a promising target for the treatment of AMD. The gene discussed is VTN; the disease is age-related macular degeneration.