VEGFA and age-related macular degeneration: Treatment options for AMD are currently limited, with the most effective therapies consisting of AREDS supplements (antioxidants plus zinc), which have been shown to reduce the risk of progression beyond early or intermediate AMD by about 25–30% over 5 years (61), and intravitreal anti-vascular endothelial growth factor injections, which can help ameliorate the symptoms of wet AMD (62).