CD8A and leishmaniasis: Several factors justify the use of CL-14 as a live vaccine for leishmaniasis: (i) a great number of genes are shared by trypanosomatids; (ii) there is a similar intracellular biological cycle, favoring a CD8 T cell induction; (iii) T. cruzi has natural immunostimulatory molecules; and (iv) the long exposure time improves the generation of long-lasting immunity (18, 24, 48, 56).