Evidence indicates that function of mammalian TRAF3 can be modulated by structurally and functionally distinct isoforms produced by alternative mRNA splicing, and at least eight splice variant isoforms were identified from a TRAF3+ lymphoma, including Δ25aa, Δ52aa, Δ56aa, Δ27aa, Δ83aa, Δ103aa, Δ130aa, and Δ221aa (13, 14). Here, TRAF3 is linked to lymphoma.