CD8A and neoplasm: In combination with DC vaccination, systemic blockade with anti-PD-1 mABs (112, 113) or anti-PD-L mABs (114–116) resulted in increased activation of cytotoxic CD8+ T cells and decreased Treg cell numbers (112) and showed better therapeutic efficacy compared with either monotherapy by preventing tumor growth and prolonging survival in tumor-bearing mice [glioblastoma (113), breast cancer (114), and melanoma (116)].