In this regard, studies performed in HT29 cells infected with BRV (A5-13 strain) demonstrated that viral infection significantly upregulated most of the IFN-inducible genes including IL-18, IFN-α-inducible protein 6, IFN-induced transmembrane protein 3, TAP1, DDX58 [retinoic acid inducible gene-I (RIG-I)], and 2′-5′-oligoadenylate synthetase (OAS) 1 as well as several cytokines such as IL-8, CCL5, CXCL10, and CXCL11 (36). This evidence concerns the gene RIGI and viral infectious disease.