AKT1 and immunodeficiency disease: Lucas et al. (30) reported nine patients with p110δ-activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency (PASLI) with N334K, E525K, or E1012K mutations in PIK3CD. The patients’ lymphocytes had an increased phosphorylation of Akt and mTOR, an increased number of senescent effector T cells and transitional B cells, and a reduced number of naïve T cells, CD4 cells, and class-switched memory B cells.