The so-called “tau hypothesis” is often considered as a competing approach, but it may be remarked that it shares most of the conceptual assumptions of the amyloid approach, i.e., the idea that the development of AD could be stopped or delayed by interfering with a primary pathological event, i.e., in this case the formation of neurofibrillary tangles. The gene discussed is MAPT; the disease is Alzheimer disease.