As this area is connected via the thalamus to the prefrontal cortex (Krienen and Buckner, 2009; Stoodley and Schmahmann, 2010) and therefore with the SN (Caulfield et al., 2016) and is associated with goal-directed behaviors, its involvement in C9orf72-associated FTD and ALS seems plausible. Here, C9orf72 is linked to frontotemporal dementia.