LPL and dementia: Although the precise mechanism regarding the mode of phagocytosis remains to be determined, recent data from mice deficient in Triggering receptor expressed on myeloid cells 2 (TREM 2)—a microglial immunoreceptor associated with phagocytosis and whose loss-of-function mutations in humans cause presenile dementia—have shown that LPL is markedly reduced in this model, suggesting that LPL is involved in TREM 2-mediated phagocytosis (Cantoni et al., 2015).