FMR1 and fragile X-associated tremor/ataxia syndrome: A deeper understanding of the relevance of genetic individuality is required before attempting a reactivation of FMR1 in patients (reviewed in Tabolacci et al., 2016b) — in particular, since full-mutation mRNA is not necessarily translated (Tassone et al., 2001; Dolskiy et al., 2017) and since transcribed alleles are able to cause FXTAS under circumstances currently unknown (Loesch et al., 2012; Santa Maria et al., 2014).