Sadly, these results are in line with two more recent studies which also achieved significant expansions (120–230 repeats; Brouwer et al., 2007; Entezam et al., 2007), but no methylation and no inactivation of Fmr1. Given that the expression of the full-mutation mRNA did apparently not cause unusual severe FXTAS or even FXS phenotypes, and given that the full-mutation alleles were neither hypermethylated nor inactivated or significantly unstable, these data support the idea that in mice, 200–350 repeats still represent a pre-mutation situation. The gene discussed is FMR1; the disease is fragile X-associated tremor/ataxia syndrome.