TNF and Nephropathy: There are three possibilities: (1) chronic inflammation driven by cell mediated immunity with T-cell activation and variety of interleukins and cytokines, including TNFα, is thought to be the cause of glomerular injury in psoriasis; (2) drugs used for psoriasis, in particular methotrexate and cyclosporine, could cause kidney damage; (3) given the higher prevalence of diabetes and hypertension among patients with psoriasis, observed renal abnormalities in psoriatic patients could be the consequence of these comorbidities [6].