Since ASF1A-facilitated H3K56Ac incorporation is important for proper restoration of chromatin structure at DNA damage sites thus genome stability29 and ASF1A is required for cellular recovery from checkpoint arrest upon DNA damage28, we thereby hypothesized that the elevated expression of USP52 and ASF1A in breast cancer potentially confers cellular resistance to genotoxic insults. This evidence concerns the gene PAN2 and breast cancer.