Notable highly connected (“hub”) genes in this module include genes involved in transcriptional regulation (HDAC2 and SFPQ)15,16 and cell cycle (CCNB1, TPX2, NCAPD2)17,18, highly suggesting that this module might regulate the tumorigenesis of HCC (Fig. 9B). This evidence concerns the gene CCNB1 and hepatocellular carcinoma.