Physical activity could reduce blood pressure through a variety of mechanisms such as reducing the main risk factors for hypertension (e.g., body weight)9,47, reducing serum concentrations of cholesterol48, by improving insulin sensitivity and reducing hyperinsulinemia47,48 through the effects of insulin on the urinary sodium excretion9,47, and by attenuating the adrenergic sympathetic activity and the total peripheral resistance resulting in a reduction of arterial pressure9,47. The gene discussed is INS; the disease is hypertensive disorder.