As in adipocytes and adipose tissue, MitoPQ induced insulin resistance in L6 myotubes as measured by HA-GLUT4 translocation (Fig. 3G) at doses that selectively increased oxidants in the mitochondria but not in the cytosol and that had no detectable effect on mitochondrial respiration (Fig. 2, G and H). This evidence concerns the gene SLC2A4 and Insulin resistance.