PARP1 and renal fibrosis: Therefore, the aim of this work is to study if the inhibition of PARP1 with 5-aminoisoquinoline (5-AIQ) prevented long-term CisPt-associated nephrotoxicity, analyzing the effects of this treatment over renal function and histopathological lesions, and focussing our attention on the mechanisms underlying renal fibrosis in this model.