In the same context, Harada and colleagues [75] reported that a significant proportion of IRF-1 mRNA transcripts obtained from the bone marrow and peripheral mononuclear cells of patients with MDS or leukemia secondary to MDS lacks exon 2 (containing the initiation codon) and exon 3 as a result of accelerated exon skipping. This evidence concerns the gene IRF1 and leukemia.