By using ChIP coupled to a CpG island microarray, Frontini and colleagues [56] identified 202 IRF-1 binding sites in the human genome, leading to the discovery that BRCA1-interacting protein C-terminal helicase 1 (BRIP1, also known as Fanconi anemia gene J) is up-regulated as a result of IFN-mediated induction of IRF-1 expression. The gene discussed is IRF1; the disease is anemia (phenotype).