Under hypoxic conditions, HIF-1α up-regulates expression of the glucose transporters GLUT1 and GLUT3 to enhance glucose uptake and controls expression of hexokinase II, glyceraldehyde 3-phosphate dehydrogenase, lactate dehydrogenase, and mitochondrial cytochrome oxidase to increase the glycolysis rate in RA synovial tissue as well as expression of glucose phosphate isomerase; along with enolase, aldolase, and triose phosphate isomerase, glucose phosphate isomerase acts as an autoantigen [180]. Here, HIF1A is linked to rheumatoid arthritis.