In this study, we aimed to decipher molecular interactions among Aβ, TREM2/TYROBP, and tau by integrating gene expression signatures associated with TREM2/TYROBP from AD Drosophila models and transcriptome-wide gene co-expression networks from two human AD cohorts including Harvard Brain Tissue Resource Center (HBTRC) [11], and the Religious Orders Study and the Rush Memory and Aging Project (ROSMAP) [41, 42]. The gene discussed is TREM2; the disease is Alzheimer disease.