To further explore the relevance of the gene expression signatures in tau, TREM2WT/TYROBP, TREM2R47H/TYROBP, tau/TREM2WT/TYROBP, and tau/TREM2R47H/TYROBP flies to AD, we investigated their association with the 111 co-expressed gene modules derived from co-regulation analyses of brain gene expression in the HBTRC AD and controls [11]. Here, MAPT is linked to Alzheimer disease.