GADD45A and Alzheimer disease: In the ROSMAP data (Additional file 10: Table S9), this salmon module had three members downregulated in AD brains, including GADD45A, FABP5, and BAALC-AS1, the first two of which were also downregulated in the present tau/TREM2WT/TYROBP and tau/TREM2R47H/ TYROBP flies (FET p = 9.2 × 10−5, 14.7-fold), consistent with the existence of substantial network consistency when human data and fly data are compared.