TYROBP and Alzheimer disease: To investigate the relevance of the gene expression signatures in Aβ42, TREM2WT/TYROBP, TREM2R47H/TYROBP, Aβ42/TREM2WT/TYROBP, and Aβ42/TREM2R47H/TYROBP fly brains to AD, we investigated their association with the 111 co-expressed gene modules derived from co-regulation analyses of brain gene expression in the Harvard Brain Tissue Resource Center (HBTRC) AD and controls.