Whereas eEF1A2 and E2F1 are not the only smart targets for HCC as other may exist [105], it is clear that a double level of targeting specificity should be pursued, i.e., the use of targeting moieties on the delivery system and the employment of siRNA directed against the mRNA of specific HCC genes/pathways. The gene discussed is E2F1; the disease is hepatocellular carcinoma.