CMIP and obesity due to melanocortin 4 receptor deficiency: CMIP (C-Maf-Inducing Protein) gene is a protein-coding gene located on 16q23.2-q23.3 and involved in multiple signaling pathways related to obesity and T2DM, such as nuclear factor-κB (NF-κB) signaling pathway [17] and T-helper 2 (Th2) signaling pathway [18].