In their description of Yki-induced Upd3 expression, Houtz et al. showed that Yki and Scalloped function within a Misshapen (Msn)-Wts-Yorkie/Scalloped-Upd3 signaling axis that enhances intestinal tissue renewal during the Drosophila midgut response to Ecc15 bacterial infection [55]. This evidence concerns the gene YAP1 and bacterial infectious disease.