Moreover, Han et al. found that G Protein-Coupled Bile Acid Receptor 1 (TGR5), a membrane-bound receptor with a crucial role in regulating bile homeostasis and glucose metabolism, is aberrantly methylated in HCC and could have a diagnostic value of AFP in the discrimination of HCC from HBV chronic infected patients [35]. Here, GPBAR1 is linked to hepatocellular carcinoma.