More recently, Cohen et al. developed a blood assay able to diagnose the most common mutations in eight cancer types, including HCC, through the analysis of circulating proteins, such as CA19-9, HGF, OPN, TIMP-1, CA-125, CEA, MPO and PRL as well as of genetic alterations in cfDNA, such as the mutations in TP53, CTNNB1, CDKN2A, PTEN and KRAS genes [62]. Here, CTNNB1 is linked to hepatocellular carcinoma.