The meta-analysis conducted by Liu et al. analyzing the methylation status of GSTP1 in 646 HCC tissues, APC in 592, and SOCS1 in 512 HCC tissues showed a strong correlation between the hypermethylation of such genes and the risk of HCC and suggested such epigenetic alterations as promising biomarkers for HCC development [74]. The gene discussed is APC; the disease is hepatocellular carcinoma.