Indeed, unsupervised transcriptome clustering of PTCL-NOS correlates with CD30 expression: the CD30-positive PTCL-NOS group features high expression of the transcription factors JUNB and MUM1/IRF4, whereas these are largely absent in the majority of CD30-negative cases. The gene discussed is TNFRSF8; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.