A microscopic examination showed that the inflammatory/edematous granulation tissue in WNT10A–/–skin ulcer was significantly larger and less cellular and accompanied by less expression ofα-SMA and more decreased number of α-SMA-positive spindle fibroblasts/myofibroblasts (Fig 2C) than that in WT mice, only in which not only WNT10A but β-catenin expression were overt especially in those activated (myo)fibroblasts (Fig 2C). The gene discussed is WNT10A; the disease is Skin ulcer.