OA and its derivatives have also been reported to upregulate the expression of GLUT4 which increases the glucose uptake in adipose and muscle cell lines [14,15] Previous studies in our laboratory have indicated that the plant-derived triterpene oleanolic acid (OA) possesses anti-hyperglycaemic properties and consequently suppress postprandial hyperglycaemia in a streptozotocin (STZ)-induced type 1 diabetic rat model [16,17]. The gene discussed is SLC2A4; the disease is type 1 diabetes mellitus.