RYR1 and cancer: Out of the 73 genes, 33 were referred to as cancer genes according to NCG, namely DNAH7, PCLO, TTN, CSMD1, GPR98, MUC16, PKHD1L1, MYOM2, NEB, RELN, SPHKAP, UNC13C, ADCY8, ANK3, BAI3, CD163L1, CNTN5, COL22A1, DNAH14, EYS, FAT1, FAT3, FLT1, GRIN2A, KMT2D, PCDH18, PKHD1, SHROOM3, THSD7B, TNC, BRAF, LRP1B and RYR1. In addition, the COSMIC database [48,49] was accessed to identify genes previously reported in melanoma.