Table 2 demonstrates the germ-line SNPs associated to melanoma risk found in the analysed patients. The relevant genes include pigmentation associated genes (SLC45A2, OCA2, TYR), as well as cell cycle and DNA repair genes (ATM, CDKN2A, ERCC5). Specific melanoma susceptibility alleles [38,39,40,41,42,43] were found in a number of patients. This evidence concerns the gene SLC45A2 and melanoma.